New project to examine the associations between extreme precipitation, floods, or drought and childhood diarrhea in Low- and Middle-Income Countries

This project is funded by the Reckitt Global Hygiene Institute.

This project aims to apply estimate the relationship between extreme precipitation, floods, or drought and risk of childhood diarrhea in LMICs, and to evaluate whether these effects are modified by water, sanitation, and hygiene (WaSH) practices.


Kai Chen, PhD, Principal Investigator

Robert Dubrow, MD, PhD, Co-Investigator

Virginia Pitzer, SCD, Co-Investigator


Abheet J. Solomon, Subaward PI at UNICEF

Pin Wang, Postdoctoral Associate

Ernest Asare, Postdoctoral Associate

3 Essential Questions: Climate Change and Health (YSPH News)

This is a news posted in Yale School of Public Health website, written by Michael Greenwood on September 29, 2021.

Kai Chen, Ph.D., assistant professor in the Department of Environmental Health Sciences, studies the relationship between climate change, air pollution and human health. He applies multidisciplinary approaches in climate and air pollution sciences, exposure assessment and environmental epidemiology to better understand how climate change is affecting human health. Much of this work has been done in China, Europe and the United States.

Why is climate change regarded as the greatest public health challenge of the 21st century?

KC: This summer, we have witnessed deadly extreme weather events occurring across the United States, such as the record-breaking heat wave in the Pacific Northwest, the raging wildfires in the West, and the devastating hurricanes and flooding in the East. All of these extreme weather events are exacerbated by climate change. But the currently reported direct death toll during these events is only the tip of the iceberg. Extreme temperatures and weather events can adversely affect a comprehensive spectrum of diseases, leading to increased mortality and morbidity.

At Yale, our research at the Yale Center on Climate Change and Health (YCCCH) shows that heat can increase the risk of cardiovascular diseases such as heart attack and stroke, respiratory diseases, diabetes, unintentional injuries and mental disorders. Recent global burden-of-disease studies found that around 2 million to 5 million deaths per year can be attributable to extreme temperature globally.

Climate change can also indirectly impact our health through worsening water quality, air pollution, increased transmission of infectious diseases, and decreased crop yields and nutrients. For example, air pollution accounts for nearly seven million premature deaths per year. Our YCCCH’s recent research also shows that air pollution is linked to increased hospital admissions of cardiovascular, kidney and mental illness.

Why is the Paris Agreement goal to keep global warming well below 2° C so important to our health?

Recent global burden-of-disease studies found that around 2 million to 5 million deaths per year can be attributable to extreme temperature globally.” – Kai Chen

KC: Any increase in global warming will primarily adversely affect human health. Our research shows that heat-related morbidity and mortality are projected to increase at 1.5 °C of warming and increase further at 2 °C or 3 °C. Ground-level ozone, a potent air pollutant, will increase when global warming exceeds 2 °C, resulting in a higher ozone-related mortality burden. As the climate changes, the world’s population is also growing older. Population aging will substantially amplify the projected mortality burden of temperature and air pollution under a warming climate.

What is the legacy of COVID-19 in addressing climate change?

KC: One big legacy of the COVID-19 response is a leap forward to a sustainable and healthier world. During the COVID-19 pandemic, lockdowns have given us the opportunity to see clean and blue skies across the world. Our study finds that in China, the first nationwide lockdown in early 2020 sharply reduced the country’s often-severe air pollution and brought substantial human health benefits in non-COVID-19 deaths. This dramatic change has shown us a glimpse of what a healthier world with strong clean air policies could be. But air pollution reduction and its associated health benefits during COVID-19 lockdowns are temporary. Moving forward, a more sustainable and healthier society will require increased investment in clean and renewable energy, low-carbon infrastructure, active transportation and climate-friendly lifestyles.

At the Yale Center on Climate Change and Health, our Climate, Health and Environment Nexus Lab aims to apply multidisciplinary approaches to produce policy-relevant knowledge that can be used to advance climate change mitigation and adaptation in a manner that promotes health and protects vulnerable populations.

3 Essential Questions is a recurring feature that explores vital topics in public health. Read earlier versions of 3 Essential Questions on cancer and antibiotic resistance.

MEDIA CONTACT: Michael Greenwood at

Welcome Mitchell Manware back to CHEN Lab!

Mitchell is a first year MPH student in the Department of Social and Behavioral Sciences at the Yale School of Public Health.  He is interested in the intersection of climate change and human health, specifically the social, individual and environmental factors influencing climate change vulnerability among disadvantaged populations.  Mitchell’s prior experience consists of participation in YSPH’s Summer Research Experience in Environmental Health (SREEH) program in 2020.  During this program he performed statistical analysis on demographic and environmental data to assess and map heat vulnerability in the State of Connecticut.

CHEN Lab at ISEE 2021

ISEE 2021 is coming! CHEN Lab members are going to present their work in different sessions:

Traditional Oral Session

  • Predicting spatiotemporally-resolved air temperature over Sweden from satellite data using an ensemble model, Zhihao Jin, 19:00 – 20:30, 26 August, TRADITIONAL ORAL SESSION 34
  • Vulnerability factors driving differential patterns in the heat-related mortality between rural and urban areas in Switzerland, Evan De Schrijver, 15:30 – 17:00, 26 August, TRADITIONAL ORAL SESSION 30

Lightning Talks

  • Associations Between Drought and Childhood Diarrhea in Low- and Middle-Income Countries, Pin Wang, 14:00 – 15:00, 23 August, LIGHTNING TALKS 3

E-Poster Discussion

  • Short-term associations between ground-level ozone exposure and urinary system disease hospital admissions through the emergency room in Beijing, China, Lingzhi Chu, 17:30 – 18:30, 24 August, E-POSTER DISCUSSION 8

E-Poster Viewing

  • Associations between short-term ambient ozone exposure and cause-specific mortality in the rural and urban areas of Jiangsu, China, Chengyi Lin, P-121
  • Long-term Ozone Exposure and Cognitive Impairment among Chinese Older Adults: Analysis of the Chinese Longitudinal Healthy Longevity Survey, Qi Gao, P-546
  • Role of meteorological factors in the transmission of SARS-CoV-2 in the United States, Yiqun Ma, P-599

Welcome Evan de Schrijver to CHEN Lab!

Evan is a visiting PhD candidate from University of Bern. Thus far, Evan’s work has aimed to understand the long term temperature-mortality trends and to identify drivers of temperature-related vulnerability factors. At Yale, Evan hopes to acquire the skillset to provide projections on climate change impacts.

Congrats to Lingzhi Chu for her first-authored paper on particulate matter air pollution and urinary system disease in Environmental Pollution!

Title: Short-term associations between particulate matter air pollution and hospital admissions through the emergency room for urinary system disease in Beijing, China: A time-series study

Journal: Environmental Pollution

Check the publication here.